He was formerly Director, Gandhigram Institute of Rural Health and Family Welfare, Gandhigram. He has also served the Central Government Health Service, Rural Health Training Centre and Armed Forces Medical College. As the first Malaria Officer in the North-East Frontier Agency, Dr. Ramachandran did pioneering work in Malaria Survey and institution of malaria control measures. He was the first BCG Publicity Officer in the Health Department of Tamil Nadu and also has a Diploma in International Public Health from Prins Leopold Institute of Tropical Medicine, Antwerp, Belgium.